Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA base-editing activity, functionality and specificity
Dhruva Katrekar, Nathan Palmer, Yichen Xiang, Anushka Saha, Dario Meluzzi, Prashant Mali
This study engineers ADAR2 deaminase variants to enhance RNA editing activity, specificity, and functionality through deep mutational scans, domain-wide mutagenesis, and split deaminase design.
eLife · Jan 19, 2022Peer-reviewedSynthetic Biology