Dhruva Katrekar

This paper describes the engineering of IS622 bridge recombinases to enable efficient and specific DNA rearrangements in the human genome, including insertion, inversion, and excision of up to 0.93 megabases.

7B-parameter convolution-attention DNA model with 131 kb context, trained on prokaryotic genomes, performs zero-shot fitness and essentiality prediction and generates Cas loci, transposons, and 650 kb sequences.

This study engineers ADAR2 deaminase variants to enhance RNA editing activity, specificity, and functionality through deep mutational scans, domain-wide mutagenesis, and split deaminase design.

The paper demonstrates the use of suppressor tRNAs and ADAR2 for in vivo RNA targeting to correct point mutations in mouse models of genetic diseases.