Human NOP2/NSUN1 Regulates Ribosome Biogenesis Through Non-Catalytic Complex Formation with Box C/D snoRNPs.
Han Liao, Anushri Gaur, Hunter McConie, Amirtha Shekar, Karen Wang, Jeffrey T. Chang, Ghislaı̀n Breton, Catherine Denicourt
The paper identifies NOP2/NSUN1's role in ribosome biogenesis by showing it deposits m5C on 28S rRNA and forms non-catalytic complexes with box C/D snoRNAs, which is not essential for rRNA processing.
Nucleic Acids Research · Sep 14, 2022Peer-reviewedMolecular Biology