TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress.
Sseu-Pei Hwang, Han Liao, Katherine Barondeau, Xinyi Han, Cassandra Herbert, Hunter McConie, Amirtha Shekar, Dimitri G. Pestov, Patrick A. Limbach, Jeffrey T. Chang, Catherine Denicourt
This study identifies TRMT1L as the methyltransferase responsible for m22G27 modification on tRNA-Tyr-GUA, showing its role in translation efficiency and oxidative stress resistance.
Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology