Jeffrey T. Chang

This study shows that lipid acyl chain remodeling via LPCAT3 affects KRAS nanoclustering and oncogenic activity by altering membrane composition.

The paper establishes a biobank of TNBC patient-derived xenografts with treatment-naive and longitudinal samples to study chemoresistance and metastasis.

This study identifies TRMT1L as the methyltransferase responsible for m22G27 modification on tRNA-Tyr-GUA, showing its role in translation efficiency and oxidative stress resistance.

PhylinSic reconstructs phylogenetic relationships from scRNA-seq data to model tumor evolution and identify subclones and lineage-specific gene expression patterns.

The paper identifies NOP2/NSUN1's role in ribosome biogenesis by showing it deposits m5C on 28S rRNA and forms non-catalytic complexes with box C/D snoRNAs, which is not essential for rRNA processing.

The paper introduces ToolJig, a web application that simplifies creating and validating Common Workflow Language (CWL) documents for reproducible bioinformatics workflows.

ImmClassifier improves fine-grained immune cell type classification in scRNA-Seq data with higher recall and precision than existing tools.