Incorporating alternative Polygenic Risk Scores into the BOADICEA breast cancer risk prediction model
Nasim Mavaddat, Lorenzo Ficorella, Tim J. Carver, Andrew Lee, AP Cunningham, Michael J. Lush, Joe Dennis, Marc D. Tischkowitz, Kate Downes, Donglei Hu, Eric Hahnen, Rita Katharina Schmutzler, Tracy L. Stockley, Gregory S. Downs, Tong Zhang, , Douglas F. Easton
This paper evaluates methods to incorporate alternative polygenic risk scores into the BOADICEA breast cancer risk prediction model, finding that retrospective likelihood approaches provide more accurate estimates.
Cancer Epidemiology Biomarkers & Prevention · Jan 13, 2023Peer-reviewedGenetic & Genomic Medicine