Author

Lorenzo Ficorella

University of CambridgeORCID 0000-0002-0577-1571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:GWAS summary statistics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Antonis C. AntoniouiD· 3 shared Douglas F. EastoniD· 3 shared Andrew LeeiD· 2 shared Jacques SimardiD· 2 shared Marc D. TischkowitziD· 2 shared Nasim MavaddatiD· 2 shared Tim J. CarveriD· 2 shared Alex Cunningham· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Antonis C. AntoniouORCID

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3 papers

Recent·Most cited

BOADICEA model: updates to the BRCA2 breast cancer risks for ages 60 years and older

Lorenzo Ficorella, Xin Yang, Douglas F. Easton, Antonis C. Antoniou

The paper updates breast cancer risk estimates for BRCA2 carriers aged 60 and older using data from two large studies.

BJC Reports · Jul 24, 2024Peer-reviewedGenetic & Genomic Medicine

Incorporating alternative Polygenic Risk Scores into the BOADICEA breast cancer risk prediction model

Nasim Mavaddat, Lorenzo Ficorella, Tim J. Carver, Andrew Lee, AP Cunningham, Michael J. Lush, Joe Dennis, Marc D. Tischkowitz, Kate Downes, Donglei Hu, Eric Hahnen, Rita Katharina Schmutzler, Tracy L. Stockley, Gregory S. Downs, Tong Zhang, , Douglas F. Easton

This paper evaluates methods to incorporate alternative polygenic risk scores into the BOADICEA breast cancer risk prediction model, finding that retrospective likelihood approaches provide more accurate estimates.

Cancer Epidemiology Biomarkers & Prevention · Jan 13, 2023Peer-reviewedGenetic & Genomic Medicine

Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1, updates to tumour pathology and cancer incidences.

Andrew Lee, Nasim Mavaddat, Alex Cunningham, Tim J. Carver, Lorenzo Ficorella, Stephanie Archer, Fiona Mary Walter, Marc D. Tischkowitz, Jonathan Roberts, Juliet A. Usher‐Smith, Jacques Simard, Marjanka K. Schmidt, Peter Devilee, Vesna Zadnik, Hannes Jürgens, , Antonis C. Antoniou

This paper updates the BOADICEA cancer risk prediction model to include new genetic variants and continuous risk factors, improving risk reclassification for specific gene carriers.

Journal of Medical Genetics · Sep 26, 2022Peer-reviewedGenetic & Genomic Medicine