Donglei Hu

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

This paper evaluates methods to incorporate alternative polygenic risk scores into the BOADICEA breast cancer risk prediction model, finding that retrospective likelihood approaches provide more accurate estimates.

The paper analyzes gene expression in African American and Latino children to show ancestry-specific genetic architecture and highlights the benefits of diverse genomic studies.

This study identifies three novel genetic loci associated with pre- and post-bronchodilator lung function in African American children with asthma using integrative genomic analysis.

The paper tests gene expression prediction models' performance across populations and finds poor generalizability to African Americans compared to European Americans.

The paper evaluates the ACMG PP3 and BP4 rules using Align-GVGD on ATM and CHEK2 data, finding that severe Align-GVGD grades exceed a moderate pathogenic threshold in a Bayesian framework.

The paper analyzes ROH in admixed populations and finds that deleterious homozygotes are more common in ROH overlapping African ancestry segments.

The paper identifies three novel common breast cancer risk variants at the 6q25 locus in Latinas and replicates their association in diverse populations.

This study identifies genetic variants associated with bronchodilator drug response in African Americans with asthma, finding both population-specific and shared genetic factors across African American and Latino populations.

This study conducts the first genome-wide association study of telomere length in African American youth, finding a novel association and failing to replicate previous findings in adults and European children.

This study identifies genetic variants and pathways associated with reduced risk of bronchopulmonary dysplasia in preterm infants, highlighting racial/ethnic differences in response to nitric oxide treatment.

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.

This study identifies pharmacogenetic variants associated with albuterol bronchodilator response in minority children with asthma using whole genome sequencing.

This paper shows that DNA methylation data can capture ancestry information and introduces a method to infer ancestry from methylation data without genetic data.

This paper examines how ancestry-assortative mating affects linkage disequilibrium in admixed populations and shows it can lead to errors in demographic inference.

This study examines how ethnic self-identification and genetic ancestry influence DNA methylation patterns in individuals of Hispanic descent, finding that ancestry explains much of the variation, but environmental factors also play a significant role.

This study identifies a novel genetic variant associated with asthma in African American children and finds limited replication of European population findings.