The bacterial antiphage protein Tiamat is an ATPase and DNase whose homologs are found across the tree of life
Shirley Yuan, Yuri Rafael de Oliveira Silva, Balwina Koopal, Vinh Dang, Arav Nangia, Jack P. K. Bravo, Andrew Santiago‐Frangos
This study identifies Tiamat as an ATPase and DNase in bacteria and shows its homologs are widespread across eukaryotes, with some acquiring non-defense roles.
bioRxiv · Oct 1, 2026 · PreprintBiochemistry