Targeting integrin alpha5 receptor in pancreatic stellate cells to diminish tumor-promoting effects in pancreatic cancer
Praneeth R. Kuninty, Ruchi Bansal, Sanne W.L. De Geus, Jonas Schnittert, Joop van Baarlen, Gert Storm, Maarten F. Bijlsma, Hanneke W. van Laarhoven, Peter J.K. Kuppen, Alexander L. Vahrmeijer, Arne Östman, Cornelis F.M. Sier, Jai Prakash
This study shows that targeting ITGA5 in pancreatic stellate cells reduces tumor fibrosis and enhances chemotherapy efficacy in pancreatic cancer.
bioRxiv · Jun 19, 2018 · PreprintCancer Biology