Daple-FLT3 (CCDC88C-FLT3) gene fusion requires the coiled-coil domain for maximal activation and pericentrosomal localization
Darren Kao, Michael Acquazzino, Arnel Ibarra, E Garcia Valenzuela, Haley Mai, Kimberly Aguilar, Elliot Stieglitz, Jason Ear
This study investigates the Daple-FLT3 gene fusion, showing its constitutive kinase activity and pericentrosomal localization, with the coiled-coil domain required for maximal activation.
bioRxiv · Sep 25, 2025 · PreprintCancer Biology