WRN Inhibition Leads to its Chromatin-Associated Degradation Via the PIAS4-RNF4-p97/VCP Axis
Fernando Rodríguez-Pérez, Dean E. Natwick, Lauren Schiff, David Trombley McSwiggen, Alec Basil Heckert, Melina Huey, Huntly M. Morrison, Mandy Loo, Rafael G. Miranda, John Filbin, José Ortega, Kayla Van Buren, Danny Murnock, Arnold Tao, Renee Butler, , Stephen E. Basham
This study identifies a novel regulatory mechanism for WRN degradation via the PIAS4-RNF4-p97/VCP axis in MSI-H cancer cells using single molecule tracking and inhibitor screening.
Nature Communications · Jul 18, 2024Peer-reviewedMolecular Biology