Chronic HDACi emends microglial differentiation and neurological disease in a mouse model of intellectual disability
Md. Suhail Alam†, Prasad Kottayil Padmanabhan, Ryan Patrick McArdle, Alejandro Lopez‐Ramirez, Arpitha MysoreRajashekara, James Knopp, G.K. Kim, Maria Virginia Centeo, A. Vania Apkarian, Vivek Swarup, Kasturi Haldar
The paper shows that a triple combination of HDAC inhibitor and excipients improves microglial function in a mouse model of Kabuki Syndrome by restoring chromatin marks and cognitive responses.
bioRxiv · May 1, 2025 · PreprintNeuroscience