CXCR4 antagonism restores dendritic cell migration and activation in a WHIM syndrome mouse model
Alexie OUCHAKOFF, Mathilde Puel, Agnieszka Jaracz‐Ros, Molène Docq, Morgan OCIMEK, Françoise Mercier‐Nomé, Yuna Delarue, Sophie SERVAIN-VIEL, Gabriela Cuesta Margolles, Anvi Laëtitia Nguyen, Aurélie Messager, Alain Pruvost, Khadidiatou KOUYATE, Katarina Zmajkovicova, Lukas Dillinger, , Géraldine Schlecht‐Louf
This study shows that inhibiting CXCR4GOF restores dendritic cell migration and activation in a WHIM syndrome mouse model, improving skin immunity.
bioRxiv · May 13, 2026 · PreprintImmunology