scVIVA: a probabilistic framework for representation of cells and their environments in spatial transcriptomics
Nathan Levy, Florian Ingelfinger, Artemii Bakulin, Giacomo Cinnirella, Pierre Boyeau, Boaz Nadler, Can Ergen, Nir Yosef
scVIVA is a deep generative model that integrates cell-intrinsic and neighboring gene expression to produce embeddings and gene profiles, revealing spatially restricted tumor-promoting endothelial cells and niche-associated T cell states in breast cancer.
bioRxiv · Jun 1, 2025 · PreprintBioinformatics