An open CAR-T single-cell atlas to enable in-depth characterization and rational engineering of CAR-T products
Sergio Camara-Peña, Paula Rodríguez-Márquez, Núria Planell, María Eréndira Calleja-Cervantes, Lorea Jordana-Urriza, Giacomo Cinnirella, Shlomit Reich-Zeliger, Paula Rodríguez‐Otero, Luis‐Esteban Tamariz‐Amador, Idoia Ochoa, Nir Yosef, Juan R. Rodríguez-Madoz, Felipe Prósper, Mikel Hernáez
The paper constructs a CAR-T cell functional atlas from over one million cells across 13 studies to link product composition with clinical response and identify sex- and age-dependent effects.
bioRxiv · Oct 11, 2025 · PreprintBioinformatics