Florian Ingelfinger

CytoVI is a deep generative model for antibody-based single cell technologies that improves integration, imputation, and analysis across different platforms and antibody panels.

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

scVIVA is a deep generative model that integrates cell-intrinsic and neighboring gene expression to produce embeddings and gene profiles, revealing spatially restricted tumor-promoting endothelial cells and niche-associated T cell states in breast cancer.

The paper identifies monocyte-derived cells as the primary source of ROS-mediated oxidative tissue damage in neuroinflammation, distinct from microglia.