Disruption of the FGFR1-FGF23-Phosphate Axis and Targeted Therapy in a Murine Model of Osteoglophonic Dysplasia
Giuliana Ascone, Rajdeep Kaur, Arwaa Mehran, Cecilia Rivas, Rebeca Galisteo, Irene Ginty, Shanna Cloud, Arthur MacLarty, Li Li, Gene Elliot, Mara Riminucci, Alessandro Corsi, Dawn E. Watkins‐Chow, Lisa J Garrett, Iris Ruth Hartley, , Carlos R. Ferreira
This study creates a murine model of Osteoglophonic Dysplasia by introducing a gain-of-function FGFR1 variant, revealing pathogenic mechanisms and demonstrating therapeutic potential with infigratinib.
bioRxiv · Nov 14, 2025 · PreprintMolecular Biology