Mara Riminucci

This paper develops a humanized ossicle model to track CAR-T cell dynamics and AML progression in real-time, enabling preclinical assessment of immunotherapies.

The paper uses time-lapse imaging to analyze lineage topology and replication kinetics in human BMSC colonies, revealing synchronized cell cycles and regulatory factors linking non-dividing cells with proliferating cells.

This study investigates how RANKL inhibition affects bone formation in a mouse model of fibrous dysplasia, finding that bone formation is restricted to specific surfaces rather than occurring diffusely.

This study evaluates the combination of zoledronate and anti-RANKL therapy in a mouse model of fibrous dysplasia, showing delayed disease rebound and improved bone density.

This study creates a murine model of Osteoglophonic Dysplasia by introducing a gain-of-function FGFR1 variant, revealing pathogenic mechanisms and demonstrating therapeutic potential with infigratinib.

This paper introduces 3DBonUS, a 3D bone printing method using ultrasound and microfluidic bioprinting to direct stem cell differentiation, showing increased osteogenic markers and mineralization.

The paper quantifies hereditary epigenetic regulation of cell-cycle exit in human bone marrow stromal cells using a novel entropy metric applied to clonal colony data.

This study shows that Pde5a deficiency prevents diet-induced obesity by enhancing adipose cAMP-PKA activation, leading to fat browning and improved metabolic outcomes.

This paper introduces a microfluidic-assisted 3D bioprinting system that enables precise control over cell compartmentalization and material composition for creating interconnected, functional tissue constructs.

This paper develops ATPS bioinks for 3D bioprinting that enable precise cellular compartmentalization and tissue regeneration.

This study shows that bone pain in Fibrous dysplasia is intrinsic and not caused by abnormal sensory nerve sprouting or neuroma formation.