Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors
O.S. Zapukhliak, Olga Netsyk, Artur Romanov, Oleksandr P. Maximyuk, Murat Öz, Gregory L. Holmes, Oleg Krishtal, Dmytro S. Isaev
This study shows mecamylamine reduces seizure-like activity in hippocampal slices by blocking nicotinic receptors, independent of glutamate and GABA transmission.
PLoS ONE · Mar 12, 2021Peer-reviewedNeuroscience