Controlled pH Alteration Enables Guanine Accumulation and Drives Crystallization within Iridosomes
Zohar Eyal, Rachael Deis, Anna Gorelick-Ashkenazi, Yuval Barzilay, Yonatan Broder, Asher Perry Kellum, Neta Varsano, Michal Hartstein, Andrea Sorrentino, Ron Rotkopf, Ifat Kaplan‐Ashiri, Katya Rechav, Rebecca A. Metzler, Lothar Houben, Leeor Kronik, , Dvir Gur
The paper investigates the role of pH changes in guanine accumulation and crystallization within zebrafish iridosomes, showing that acidic conditions and V-ATPase activity drive crystal formation.
Nature Chemical Biology · Sep 2, 2025Peer-reviewedCell Biology