The paper identifies iridosomes as a subtype of lysosome-related organelles (LROs) in zebrafish, showing their role in guanine crystal formation through molecular and structural analysis.

Proceedings of the National Academy of Sciences · Apr 8, 2026Peer-reviewedDevelopmental Biology

Controlled pH Alteration Enables Guanine Accumulation and Drives Crystallization within Iridosomes

Zohar Eyal, Rachael Deis, Anna Gorelick-Ashkenazi, Yuval Barzilay, Yonatan Broder, Asher Perry Kellum, Neta Varsano, Michal Hartstein, Andrea Sorrentino, Ron Rotkopf, Ifat Kaplan‐Ashiri, Katya Rechav, Rebecca A. Metzler, Lothar Houben, Leeor Kronik, , Dvir Gur

The paper investigates the role of pH changes in guanine accumulation and crystallization within zebrafish iridosomes, showing that acidic conditions and V-ATPase activity drive crystal formation.

Nature Chemical Biology · Sep 2, 2025Peer-reviewedCell Biology

The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis

Swastik Kar, Rachael Deis, Adam Ahmad, Yoel Bogoch, Avichai Dominitz, Gal Shvaizer, Esther Sasson, Avishag Mytlis, Ayal Ben‐Zvi, Yaniv M. Elkouby

This study identifies the mechanism of Balbiani body formation in zebrafish oocytes through microtubule-controlled molecular condensation of Buc.

Current Biology · Jan 1, 2025Peer-reviewedDevelopmental Biology