Ron Rotkopf

Elucidating early intestinal stem cell response to bacterial infection

This study investigates how Lgr5+ intestinal stem cells respond to Salmonella infection by initiating cellular remodeling and antimicrobial defense mechanisms.

Chromatin tethering to the nuclear envelope enhances its accessibility to RNAPII and promotes chromatin asymmetric organization

The paper shows that chromatin tethering to the nuclear envelope prevents clustering and enhances RNAPII accessibility, promoting asymmetric chromatin organization in Drosophila muscle nuclei.

Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution

The paper investigates how extrachromosomal DNA (ecDNA) inheritance mechanisms influence cancer evolution through mitotic segregation and micronuclei formation.

Comparative developmental transcriptomics of Drosophila mushroom body neurons highlights the mevalonate pathway as a regulator of axon growth

The paper compares axon growth programs in Drosophila mushroom body neurons using transcriptomics, identifying the mevalonate pathway as critical for axon regrowth.

Controlled pH Alteration Enables Guanine Accumulation and Drives Crystallization within Iridosomes

The paper investigates the role of pH changes in guanine accumulation and crystallization within zebrafish iridosomes, showing that acidic conditions and V-ATPase activity drive crystal formation.

Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution

The paper profiles single-cell RNA sequencing data from sex-shared neurons in C. elegans to reveal molecular dimorphism and sex-biased gene expression patterns.

Wnt/β-catenin is required for proprioception by coordinating the multi-compartment development of muscle spindles

This study shows that the Wnt/β-catenin pathway is essential for proprioception by coordinating the development of muscle spindle components through both cell-autonomous and non-cell-autonomous mechanisms.

TENT4A non-canonical poly(A) polymerase regulates DNA-damage tolerance via multiple pathways which are mutated in endometrial cancer

This study identifies TENT4A as a regulator of DNA-damage tolerance through multiple pathways, with mutations in these pathways linked to endometrial cancer.

Robo2 regulates synaptic oxytocin content by affecting actin state

This study shows that Robo2 regulates synaptic oxytocin content by affecting actin dynamics in zebrafish.