RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance
Dreyton Amador, James M. Powers, Ashley G. Njiru, Zahra Ansari, Yvon Woappi
RESTRICT-seq improves CRISPR screens by restricting Cas9 activity in time-gated cycles, revealing novel epigenetic drivers of cSCC resistance.
bioRxiv · Sep 17, 2025 · PreprintCancer Biology