mRNA-LNP Vaccines Encoding for Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADE
Enzo LaMontia-Hankin, Clayton J. Wollner, E. Taylor Stone, Angélica Peña Rosado, Jill Pflugheber, Ashley Zalla, Sebastian Nieto, Amelia K. Pinto, James D. Brien, Justin M. Richner
The paper develops mRNA-LNP vaccines encoding optimized prM/ENV proteins for all four DENV serotypes that induce protective immunity and reduce antibody-dependent enhancement.
bioRxiv · Jul 21, 2025 · PreprintMicrobiology