Somatic CRISPR editing of Msh3 mitigates Huntington's disease pathology in mice
Esaria Oliver, Marina V. Kovalenko, Mathilde Louçã, Andrew Jiang, Jordan Westerdahl, Kevin Correia, Ben P Jones, Faaiza Saif, Nicole Romano, Ashna Sidhu, Tammy Gillis, Emanuela Elezi, Ryan Murtha, Ricardo Mouro Pinto, Vanessa Chantal Wheeler
This study shows that knocking out Msh3 in mice with Huntington's disease slows CAG expansion and reduces pathology, with earlier intervention being more effective.
bioRxiv · Jun 10, 2026 · PreprintGenetics