Andrew Jiang

This study shows that knocking out Msh3 in mice with Huntington's disease slows CAG expansion and reduces pathology, with earlier intervention being more effective.

TRACE is an open-source software that quantifies somatic instability of tandem repeats using capillary electrophoresis data, providing accessible tools for analyzing repeat expansion.

This paper investigates the protective effect of the LIG1 K845N variant in Huntington's disease by showing it increases ligase fidelity and suppresses somatic CAG repeat expansion.

ICARUS v3 efficiently analyzes large-scale single cell RNA-seq datasets with over 1 million cells using geometric cell sketching and downstream analysis tools.

The paper identifies transcriptional upregulation of glutamate receptors and downregulation of oxidative phosphorylation in an ovine HD model before neuronal loss and motor symptoms.

This study compares single cell RNA-seq data from frozen tissue cells and nuclei, finding nuclei provide higher quality data with more gene and UMI counts and better clustering resolution.

ICARUS v2.0 provides a web-based tool for analyzing single cell RNA-seq data with features for gene network analysis, trajectory inference, cell communication, and GWAS integration.