Mechanism of substrate binding by the SARS-CoV-2 NiRAN domain and modulation of its activities during replication
Ashwin Uday, Muhammed Navas, P. S. Sivaprasad, Ufaq Bhat, Kayarat Saikrishnan
This study elucidates how the SARS-CoV-2 NiRAN domain binds substrates and modulates its RNAylation and NMPylation activities, revealing structural preferences and regulatory mechanisms.
bioRxiv · Oct 31, 2025 · PreprintMolecular Biology