Kayarat Saikrishnan

This study characterizes Mbo45V, a Type III restriction-modification enzyme from Mycoplasma bovis, revealing its DNA recognition, cleavage, and kinetic properties, as well as its adaptation to intracellular conditions.

The paper shows that phase-variable SSRs in bacteria can create complex XNOR logic gates through frameshift suppression, challenging the binary switch model of phase variation.

This study elucidates how the SARS-CoV-2 NiRAN domain binds substrates and modulates its RNAylation and NMPylation activities, revealing structural preferences and regulatory mechanisms.

This study shows that a Type ISP bacterial restriction-modification enzyme can displace nucleosome octamers using ATP, while a Type III enzyme cannot, suggesting the former could act as an artificial chromatin remodeler.