Cognitive impairments in a mouse model for Huntington's disease correlate with presymptomatic locomotion and number of CAG repeats
Olga Jung, Sabine Hoffmeister‐Ullerich, Asina Omriouate, Josefine Plumhoff, Michael R. Kreutz, Katarzyna M. Grochowska, Fabio Morellini
This study shows that cognitive impairments in HD knock-in mice correlate with locomotion and CAG repeat length, revealing early behavioral changes and repeat-length-dependent disease variability.
bioRxiv · Jul 22, 2026 · PreprintAnimal Behavior & Cognition