Katarzyna M. Grochowska

This study shows that cognitive impairments in HD knock-in mice correlate with locomotion and CAG repeat length, revealing early behavioral changes and repeat-length-dependent disease variability.

This study identifies Aβ42-carrying extracellular vesicles in plasma as biomarkers associated with neurodegeneration and neuroinflammation in Alzheimer's disease.

The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.

This study shows that astrocytic uptake of modified Aβ3(pE)-42 disrupts the endolysosomal system, leading to inflammation and synapse loss in Alzheimer's disease.

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.