Michael R. Kreutz

Cognitive impairments in a mouse model for Huntington's disease correlate with presymptomatic locomotion and number of CAG repeats

This study shows that cognitive impairments in HD knock-in mice correlate with locomotion and CAG repeat length, revealing early behavioral changes and repeat-length-dependent disease variability.

Amphisome biogenesis couples synaptic autophagy to local protein synthesis

The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.

A Jacob/nsmf gene knockout does not protect against hypoxia- and NMDA-induced neuronal cell death

This study shows that nsmf gene knockout does not protect against hypoxia and NMDA-induced neuronal death, suggesting JaCS is mainly relevant in chronic extrasynaptic NMDAR activation.

Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization.

The paper shows that NPYergic circuitry in the dorsal dentate gyrus regulates remote fear memory generalization in mice through engram cell activity and neurotransmission recovery.

Autism associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

This study shows two ASD-associated SHANK3 mutations cause structural changes and altered protein turnover at synapses.

Synaptic control of DNA-methylation involves activity-dependent degradation of DNMT3a1 in the nucleus

This study shows that synaptic activity controls DNA methylation by degrading DNMT3a1 via NMDAR-dependent neddylation.

Serum α-Klotho levels correlate with episodic memory changes related to cardiovascular exercise in older adults

The paper examines how changes in serum α-Klotho levels relate to cognitive and neuroanatomical changes in older adults undergoing cardiovascular exercise or control interventions.

SIPA1L2 controls trafficking and signaling of TrkB-containing amphisomes at presynaptic terminals

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.

Radial F-actin Organization During Early Neuronal Development

The paper shows radial F-actin organization around the centrosome during early neuronal development, with dynamic actin structures and interactions with centrosomal components.