Distinct pathogenic genes causing intellectual disability and autism exhibit overlapping effects on neuronal network development
Monica Frega, Martijn M. Selten, Britt Mossink, Jason M. Keller, Katrin Linda, Rebecca Moerschen, Jieqiong Qu, Pierre Koerner, Sophie Martina Johanna Jansen, Elske Bijvank, Astrid Oudakker, Tjitske Kleefstra, Hans van Bokhoven, Huiqing Zhou, Dirk Schubert, Nael Nadif Kasri
The paper investigates how mutations in distinct genes causing intellectual disability and autism affect neuronal network development, finding shared effects on excitability and synaptic function.
Cell Reports · Jan 1, 2020Peer-reviewedNeuroscience