Author

Jason M. Keller

Radboud University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Dirk SchubertiD· 5 shared Monica FregaiD· 5 shared Nael Nadif KasriiD· 5 shared Britt MossinkiD· 4 shared Hans van BokhoveniD· 4 shared Katrin LindaiD· 4 shared Eline van HugteiD· 3 shared Teun M. Klein GunnewiekiD· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Dirk SchubertORCID

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5 papers

Recent·Most cited

SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

Eline van Hugte, Elly Lewerissa, Ka Man Wu, Nicky Scheefhals, Giulia Parodi, Torben W. van Voorst, Sofia Puvogel, Naoki Kogo, Jason M. Keller, Monica Frega, Dirk Schubert, Helenius Jurgen Schelhaas, Judith S. Verhoeven, Marian Majoie, Hans van Bokhoven, Nael Nadif Kasri

This study investigates SCN1A mutations in excitatory neuronal networks derived from patient hiPSCs, revealing mutation-specific phenotypes that correlate with clinical outcomes and drug responses.

Brain · Jul 19, 2023Peer-reviewedNeuroscience

Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks

Britt Mossink, Jon-Ruben van Rhijn, Shan Wang, Katrin Linda, Maria Rosaria Vitale, Johanna E. M. Zöller, Eline van Hugte, Jitske Bak, Anouk H. A. Verboven, Martijn M. Selten, Moritz Negwer, Brooke L. Latour, Ilse van der Werf, Jason M. Keller, Teun M. Klein Gunnewiek, , Nael Nadif Kasri

This study investigates the role of CDH13 in regulating GABAergic inhibition in human-derived neuronal networks and shows its impact on E/I balance.

Molecular Psychiatry · May 10, 2021Peer-reviewedNeuroscience

Mitochondrial dysfunction impairs human neuronal development and reduces neuronal network activity and synchronicity

Teun M. Klein Gunnewiek, Eline van Hugte, Monica Frega, Gemma Sole Guardia, Katharina Foreman, Daan M. Panneman, Britt Mossink, Katrin Linda, Jason M. Keller, Dirk Schubert, David M Cassiman, Richard J. Rodenburg, Noemi Vidal‐Folch, Devin Oglesbee, Ester Perales‐Clemente, , Tamás Kozicz

This study shows that mitochondrial dysfunction in human neurons, caused by high heteroplasmy of the m.3243A>G variant, leads to impaired neural development, reduced synaptic connectivity, and decreased network activity.

Cell Reports · Apr 1, 2020Peer-reviewedNeuroscience

Distinct pathogenic genes causing intellectual disability and autism exhibit overlapping effects on neuronal network development

Monica Frega, Martijn M. Selten, Britt Mossink, Jason M. Keller, Katrin Linda, Rebecca Moerschen, Jieqiong Qu, Pierre Koerner, Sophie Martina Johanna Jansen, Elske Bijvank, Astrid Oudakker, Tjitske Kleefstra, Hans van Bokhoven, Huiqing Zhou, Dirk Schubert, Nael Nadif Kasri

The paper investigates how mutations in distinct genes causing intellectual disability and autism affect neuronal network development, finding shared effects on excitability and synaptic function.

Cell Reports · Jan 1, 2020Peer-reviewedNeuroscience

Neuronal network dysfunction in a human model for Kleefstra syndrome mediated by enhanced NMDAR signaling

Monica Frega, Katrin Linda, Jason M. Keller, Guvem Gumus Akay, Britt Mossink, Jon-Ruben van Rhijn, Moritz Negwer, Teun M. Klein Gunnewiek, Katharina Foreman, Nine F. Kompier, Chantal Schoenmaker, Willem M.R. van den Akker, Ilse van der Werf, Astrid R. Oudakker, Huiqing Zhou, , Nael Nadif Kasri

This study shows that EHMT1 deficiency in human neurons leads to NMDAR hyperfunction, causing neuronal network dysfunction in Kleefstra syndrome, and demonstrates pharmacological rescue of these phenotypes.

Nature Communications · Oct 30, 2019Peer-reviewedNeuroscience