Hedgehog signaling drives glial cell plasticity and oncogenic reprogramming in gastroenteropancreatic neuroendocrine neoplasms
Suzann Duan, Anneleigh Belle Twer, Ateh Zinkeng, Ikrame Naciri, Juliette W. Moore, Rebeca G Gentry, Ricky A. Sontz, Reed I. Ayabe, Edgar O. Tapia, Travis William Sawyer, Juanita L. Merchant
This study shows Men1-deficient glial cells reprogram via SHH-GLI signaling to become gastroenteropancreatic neuroendocrine tumors.
Molecular Cancer · Feb 21, 2026Peer-reviewedCancer Biology