Soluble TREM2 reduces DAP12 surface expression by dissociating the TREM2-DAP12 complex
Atsuma Yamada, Fuminori Tsuruta
This study shows that soluble TREM2 reduces DAP12 surface expression by dissociating the TREM2-DAP12 complex, thereby inhibiting microglial phagocytosis and amyloid-β incorporation.
bioRxiv · May 7, 2026 · PreprintMolecular Biology