Author

Fuminori Tsuruta

University of TsukubaORCID 0000-0002-3471-7654Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Takumi TaketomiiD· 3 shared Andrea J. KriziD· 1 shared Atsuma Yamada· 1 shared Ayako Kitazawa· 1 shared Ban SatoiD· 1 shared Çağla EroğluiD· 1 shared Chihiro MaedaiD· 1 shared Christopher A. WalshiD· 1 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersNeuroscience

Takumi TaketomiORCID

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Author profile →

5 papers

Recent·Most cited

Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex

Diane D. Shao, Yifan Zhao, Joseph Brew, Yahia Adla, Urmi Ghosh, Vinay Viswanadham, Lovelace J. Luquette, Sijing Zhao, Andrea J. Kriz, Xuyu Qian, Takumi Taketomi, Shannon Coy, Sandro Santagata, Michael B. Miller, Fuminori Tsuruta, , Christopher A. Walsh

The paper investigates somatic copy number variants (CNVs) in human neurons across development, finding that perinatal elimination of neurons with aberrant genomes reduces CNV prevalence and targets dosage-sensitive genes.

Nature · Oct 28, 2026Peer-reviewedNeuroscience

Soluble TREM2 reduces DAP12 surface expression by dissociating the TREM2-DAP12 complex

Atsuma Yamada, Fuminori Tsuruta

This study shows that soluble TREM2 reduces DAP12 surface expression by dissociating the TREM2-DAP12 complex, thereby inhibiting microglial phagocytosis and amyloid-β incorporation.

bioRxiv · May 7, 2026 · PreprintMolecular Biology

Mycophenolate mofetil reduces the branching of microglial processes

Rin-ichiro Teruya, Kentaro Ueda, Takumi Taketomi, Takushi Yamamoto, Naoki Yamashita, Hana Konno, Fuminori Tsuruta

The paper shows that mycophenolate mofetil reduces microglial branching without affecting proliferation, suggesting guanosine nucleotides are critical for microglial diversity.

Molecular Brain · Jan 11, 2026Peer-reviewedNeuroscience

Propagation of neuronal micronuclei regulates microglial states

Sarasa Yano, Natsu Asami, Yusuke Kishi, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken‐ichiro Kubo, Mai Saeki, Chihiro Maeda, Kaito Akiyama, Tomomi Okajima, Ban Sato, Yukiko Gotoh, Kazunori Nakajima, , Fuminori Tsuruta

This study shows neuronal micronuclei influence microglial states by altering their morphology and transcriptome during postnatal development.

bioRxiv · Jul 31, 2023 · PreprintNeuroscience

Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

Takumi Taketomi, Takunori Yasuda, Rikuri Morita, Jae Hyun Kim, Yasuteru Shigeta, Çağla Eroğlu, Ryuhei Harada, Fuminori Tsuruta

This study shows that an ASD-associated mutation in SPARCL1 impairs Hevin secretion by causing ER stress through structural instability.

Scientific Reports · Jul 13, 2022Peer-reviewedMolecular Biology