Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation
Audrey Dalgarno, Shane A. Evans, Maxfield M. G. Kelsey, Thomas A. Nuñez, Azucena V. Rocha, Kelly Clark, John M. Sedivy, Nicola Neretti
This study presents high-resolution Hi-C maps of human fibroblasts during senescence, revealing chromatin remodeling that promotes inflammation and transposable element activation.
bioRxiv · Jun 11, 2025 · PreprintGenomics