Author

Shane A. Evans

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Assay:Hi-C· 2 Organism:mouse· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

Nicola NerettiiD· 5 shared John M. SedivyiD· 3 shared Azucena V. Rocha· 2 shared Kelly Clark· 2 shared Anuj SrivastavaiD· 1 shared Ashley E. WebbiD· 1 shared Audrey Dalgarno· 1 shared Darshan BryneriD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersGenomics

Nicola NerettiORCID

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Author profile →

5 papers

Recent·Most cited

Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation

Audrey Dalgarno, Shane A. Evans, Maxfield M. G. Kelsey, Thomas A. Nuñez, Azucena V. Rocha, Kelly Clark, John M. Sedivy, Nicola Neretti

This study presents high-resolution Hi-C maps of human fibroblasts during senescence, revealing chromatin remodeling that promotes inflammation and transposable element activation.

bioRxiv · Jun 11, 2025 · PreprintGenomics

Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of CellularSenescence

Nicola Neretti, Shane A. Evans, Yee Voan Teo, Samuel J. Hinthorn, Kelly Clark, Takahiro Ito, John M. Sedivy

The paper identifies common transcriptional subpopulations across different senescence types and shows their differential response to a senolytic agent.

Aging Biology · Jun 29, 2023Peer-reviewedGenomics

LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5'-single cell RNA-Seq

Wilson McKerrow, Larisa Kagermazova, Nicole Adell Doudican, Nicholas Frazzette, Efiyenia Ismini Kaparos, Shane A. Evans, Azucena V. Rocha, John M. Sedivy, Nicola Neretti, John A. Carucci, Jef D. Boeke, David Fenyö

The paper develops a method to measure LINE-1 retrotransposon expression in single cells and identifies its presence in epithelial and neuronal cells, with age-related increases.

Nucleic Acids Research · Jan 17, 2023Peer-reviewedBioinformatics

Single cell analysis of the aging female hypothalamus

Kaitlyn H. Hajdarovic, Doudou Yu, Lexi-Amber Hassell, Shane A. Evans, Sarah Packer, Nicola Neretti, Ashley E. Webb

This study uses single nuclei RNA-sequencing to identify cell-specific aging signatures in the hypothalamus of aged female mice, revealing Xist as a novel marker of neuronal aging in females.

bioRxiv · Mar 7, 2021 · PreprintNeuroscience

Bayesian Estimation of 3D Chromosomal Structure from Single Cell Hi-C Data

Michael Rosenthal, Darshan Bryner, Fred Huffer, Shane A. Evans, Anuj Srivastava, Nicola Neretti

The paper develops a Bayesian method to infer 3D chromosomal structures from single-cell Hi-C data, incorporating bulk Hi-C as a prior to improve accuracy.

bioRxiv · May 7, 2018 · PreprintBioinformatics