Maxfield M. G. Kelsey

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

This study identifies LINE-1 retrotransposons as drivers of neuronal senescence in Alzheimer's disease through cytoplasmic DNA sensing and the cGAS-STING pathway.

The Translatome of Senescent Cells Revealed by Sequencing Actively Translated mRNA

This study uses AHARIBO to profile the translatome of human fibroblasts, revealing post-transcriptional regulation of senescence programs and identifying L1HS elements involved in inflammatory cDNA production.

Characterization of Cellular Senescence in Primary Human Astrocytes

This study characterizes replicative senescence in primary human astrocytes, identifying molecular features and L1HS retrotransposon activation associated with senescence.

Retrotransposon Activation in the Aged and Alzheimer's Disease Brain Examined by Nanopore Long-read DNA Sequencing

The paper uses Nanopore long-read DNA sequencing to analyze retrotransposon activation in aged and Alzheimer's disease brains, identifying somatic insertions and epigenetic changes.

TE-Seq: A Transposable Element Annotation and RNA-Seq Pipeline

TE-Seq is an RNA-Seq pipeline that annotates transposable elements and analyzes their expression, supporting long-read DNA data for TE-complete genome assembly.

Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation

This study presents high-resolution Hi-C maps of human fibroblasts during senescence, revealing chromatin remodeling that promotes inflammation and transposable element activation.