Progressive hypothalamic neuroinflammation after ovariectomy in mice parallels age-related transcriptomic changes in the female human hypothalamus
Jordana C. Bloom, Encarnación Torres, Sidney Alcântara Pereira, Liliana Arvizu-Sanchez, Audrey N. Fontes, Hadine Joffe, David C. Page, Victor Manuel Navarro
This study examines hypothalamic changes in mice after ovariectomy, finding time-dependent neuroinflammation and gene expression patterns that mirror human age-related changes.
bioRxiv · Oct 5, 2024 · PreprintNeuroscience