David C. Page

The paper tracks genome-wide evolutionary dynamics in hybrid Drosophila populations, showing rapid purging of minority ancestry and repeated retention of selected regions through adaptive introgression.

trackDJ is an R package that simplifies the creation of publication-quality epigenomic figures through a user-friendly interface and high-level plotting functions.

The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

The paper sequences the rat Y chromosome and reveals a short pseudoautosomal region with high recombination rate and unique evolutionary features.

The paper identifies sex differences in cardiac metabolism, showing female hearts have higher fatty acid oxidation gene expression and energy utilization compared to male hearts.

This study shows that perturbations of ASD genes in human neural progenitor cells converge on shared transcriptomic effects, with ZFX potentially mediating the female protective effect.

The paper shows that DDX3X and DDX3Y exhibit post-transcriptional cross- and auto-regulation, buffering their expression levels in human cells.

The paper re-examines the boundary of the human pseudoautosomal region 1 (PAR1) using genomic data and finds evidence supporting its original position, narrowing it to a 201-bp window.

This study examines hypothalamic changes in mice after ovariectomy, finding time-dependent neuroinflammation and gene expression patterns that mirror human age-related changes.

The paper identifies sex-chromosomal and autosomal gene responses to Xi and Y dosage in four human cell types, showing robustness in sex-chromosomal effects and cell-type-specific autosomal responses.

The paper shows that the MEIOC-YTHDC2-RBM46 complex destabilizes mRNAs of transcriptional repressors in mouse spermatogenic cells, enhancing their competence to initiate meiosis in response to retinoic acid.

The paper identifies sex differences in microglial inflammatory responses in glioblastoma, showing that genes on the inactive X chromosome drive these differences.

The paper shows that the inactive X and Y chromosomes similarly affect autosomal gene expression in human cells through shared transcription factors.

The paper shows that the inactive X chromosome modulates the expression of the active X chromosome in humans, affecting 38% of X-linked genes and contributing to sex differences in disease.

This study shows CBX2 is required for spermatogonial differentiation and long-term maintenance of male germ cells through chromatin compaction and phase separation.

SHIMS 3.0 uses ultra-long nanopore reads to improve assembly of structurally complex genomic regions with high accuracy and reduced manual effort.

The paper identifies 26 conserved palindromes on the human X Chromosome and finds that natural selection preserves protein-coding gene families within them, while spacers show structural instability.

The paper shows GC-biased gene conversion drives GC content elevation in X-chromosome palindromes across human, chimpanzee, and rhesus macaque.

The paper identifies dosage-sensitive developmental genes as key to survival on sex-specific chromosomes across snakes, birds, and mammals, showing broad expression and dosage sensitivity contribute independently to gene retention.

This study shows DAZL regulates spermatogonial progenitor expansion and differentiation by enhancing translation of its target genes.

The paper shows GCNA interacts with Topoisomerase II to resolve DNA-protein crosslinks, maintaining genome stability in germline and early embryos.

This paper uses nanopore sequencing to identify the integration site of a transgene in mouse genomes and provides additional insights into transgene structure and contamination.

This paper introduces a method to isolate high-purity populations of male germ cells from mice by synchronizing development, staging, and sorting, achieving ~90% purity at each developmental step.

The paper uses miRNA target site analysis to show preexisting gene dosage sensitivities influenced the evolution of mammalian and avian sex chromosomes.

The paper introduces SHIMS 2.0, a cost-effective and high-throughput method for generating high-quality reference sequences from complex genomic regions.