Jordana C. Bloom

Progressive hypothalamic neuroinflammation after ovariectomy in mice parallels age-related transcriptomic changes in the female human hypothalamus

This study examines hypothalamic changes in mice after ovariectomy, finding time-dependent neuroinflammation and gene expression patterns that mirror human age-related changes.

Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse Germline

This study investigates DNA damage responses in mouse primordial germ cells, showing sex-specific differences in mutation avoidance and developmental outcomes after ionizing radiation exposure.

Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt

This study identifies miR-375 as a key regulator of intestinal crypt homeostasis, showing its role in stem cell proliferation, tuft cell abundance, and resistance to infection and cancer.

Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination

The paper shows that CHK1/CHK2 signaling to TRP53/TAp63 eliminates oocytes with unrepaired meiotic DSBs or asynaptic chromosomes.

Female-biased embryonic death from genomic instability-induced inflammation

The paper shows female mouse embryos are more susceptible to embryonic lethality from genomic instability-induced inflammation, which is mitigated by testosterone or anti-inflammatory drugs.