The Impact of Coronavirus Nsp1 on Host mRNA Degradation Is Independent of Its Role in Translation Inhibition
Emilie Bäumlin, Dominic Andenmatten, Jonas Luginbühl, Aurélien Lalou, Nino Schwaller, Evangelos D. Karousis
This study investigates how SARS-CoV-2 and MERS-CoV Nsp1 proteins affect host mRNA degradation, revealing that Nsp1 binding to ribosomes triggers degradation independently of translation inhibition.
Cell Reports · Mar 29, 2025Peer-reviewedMolecular Biology