Differential expression of an alternative splice variant of IL-12Rβ1 impacts early dissemination in the mouse and associates with disease outcome in both mouse and humans exposed to tuberculosis
Mrinal K. Das, Aurelie A. Ray, Yi Cai, Akul Singhania, Christine M. Graham, Mingfeng Liao, Jeffrey J. Fountain, John E. Pearl, Manish Pareek, Pranab Haldar, Anne O’Garra, Xinchun Chen, Andrea M. Cooper
This study identifies an alternative splice variant of IL-12Rβ1 that limits early Mtb dissemination in mice and predicts TB disease outcomes in humans.
bioRxiv · Feb 26, 2018 · PreprintImmunology