Author

Xinchun Chen

Shenzhen UniversityORCID 0000-0002-2101-9013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Yi CaiiD· 2 shared Akul Singhania· 1 shared Andrea M. CooperiD· 1 shared Andrew J. SawyeriD· 1 shared Anne O’Garra· 1 shared Aurelie A. Ray· 1 shared Camelia Y. J. QuekiD· 1 shared Carl G. FengiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Yi CaiORCID

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2 papers

Recent·Most cited

Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis

Wei Lie Xiao, Andrew J. Sawyer, Siwei Mo, Xinyu Bai, Qinzhu Yang, Yi Gao, Timothy Fielder, Yue Zhang, Youchao Dai, Qianting Yang, Yi Cai, Guanggui Ding, Guofang Deng, Liang Fu, Camelia Y. J. Quek, , Xinchun Chen

Xiao et al. reveal spatial segregation of immune cells in TB-lung tissue and link the microenvironmental dynamics to disease states of tuberculosis.

bioRxiv · Apr 11, 2025 · PreprintImmunology

Differential expression of an alternative splice variant of IL-12Rβ1 impacts early dissemination in the mouse and associates with disease outcome in both mouse and humans exposed to tuberculosis

Mrinal K. Das, Aurelie A. Ray, Yi Cai, Akul Singhania, Christine M. Graham, Mingfeng Liao, Jeffrey J. Fountain, John E. Pearl, Manish Pareek, Pranab Haldar, Anne O’Garra, Xinchun Chen, Andrea M. Cooper

This study identifies an alternative splice variant of IL-12Rβ1 that limits early Mtb dissemination in mice and predicts TB disease outcomes in humans.

bioRxiv · Feb 26, 2018 · PreprintImmunology