Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing
Sophie Guia, Aurore Fenis, Camille Baudesson de Chanville, Justine Galluso, Hakim Medjouel Khlifi, Bertrand Escalière, Angelika Modelska, Margaux Vienne, Noëlla Lopes, Amélie Pouchin, Benjamin Rossi, Laurent Gauthier, Sandrine Roulland, Éric Vivier, Émilie Narni-Mancinelli
This study identifies ICAM-1 and IFN-γ signaling as critical factors influencing NK cell-mediated tumor cell destruction in HCT-116 cells.
Journal for ImmunoTherapy of Cancer · Mar 1, 2025Peer-reviewedImmunology