Rapid emergence of HCMV drug resistance in immunocompromised paediatric patients detected using target enrichment and deep sequencing
Charlotte Houldcroft, Josephine M Bryant, Daniel P Depledge, Ben K Margetts, Jacob Simmonds, Stephanos Nicolaou, Helena Tutill, Rachel Williams, Austen Worth, Stephen D Marks, Paul Veys, Elizabeth Whittaker, Judith Breuer
This study uses target-enrichment and deep sequencing to detect HCMV drug resistance mutations in immunocompromised paediatric patients, identifying resistance earlier than PCR in some cases.
bioRxiv · May 27, 2016Microbiology