Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota
Katja Thümmler, Shyam Basak, Heather Hulme, Clio Dritsa, Rachel E. Foreman, Humaira Naseer, E. Salah, Anthony Tumber, Sam Worboys, Gill R. Douce, Jennifer H. Haggarty, Rachel Williams, Vicky Taylor, Michael J. Ormsby, Phillip D. Whitfield, , Daniel M. Wall
This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.
bioRxiv · Nov 11, 2025 · PreprintMicrobiology