PER2- and state-dependent transcriptional programs gate neural stem cell proliferation with niche-specific circadian autonomy
Pedro Ozório Brum, Ava Abdi, Federico Scaramuzza, Tatjana Kepčija, Michael Harvey Hastings, Andrew S. I. Loudon, Kristin Tessmar‐Raible, Noelia Urbán
The paper shows PER2-dependent circadian regulation of adult neural stem cell proliferation in two niches, with SVZ requiring external stimuli for synchronization.
bioRxiv · Sep 17, 2026 · PreprintCell Biology